The term 'gain of the detection system' refers to the ratio of registered counts per bombardment from a radioactive source, and it can also pertain to the signal strength of each interaction. In older electronic systems, stronger individual pulses affected detector efficiency, as they struggled to differentiate between low and high energy interactions. This limitation highlights the importance of understanding gain in the context of detector performance. The discussion also prompts inquiries about relevant textbooks being used in the field. Overall, the conversation emphasizes the significance of gain in gamma ray detection and its implications for detector efficiency.