It depends on the length of the transmission line.
If it is a quarter wavelength long, you do get effects like you mention.
However, if the input did look like a short circuit, it is hard to imagine how you could get any power into the line.
Assuming you managed it somehow, then the voltage at the other end could get very high, not just double.
Suppose there was a 1000 ohm resistor across the open end of the line (possibly your fingers) and it was 50 ohm line, then the input would look like (50 ohms * 50 ohms / 1000 ohms) or 2.5 ohms.
If you put 1 watt into the line, that would be 1.58 volts (1.58^2 / 2.5 ohms = 1 watt) at the input.
But at the 1000 ohm resistor, the voltage would be 31 volts because the power would be the same, (31^2 / 1000 = 1 watt), but the impedance is higher so the voltage has to be higher.
So, you wouldn't have to have a very high input voltage to get a big voltage out.
Even 31 volts RMS would be enough for you to feel.
To answer your question, you would possibly get a large voltage across your fingers, depending on the length of the transmission line and the input power.