Haemolytic disease and the rheasus blood group

Thread starter Cheman
Start date Nov 7, 2004
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Blood Disease Group

AI Thread Summary

Haemolytic disease in newborns occurs when an Rh- mother has developed anti-D antibodies, typically after exposure to Rh+ blood during a previous pregnancy or transfusion. These antibodies can cross the placenta and attack the red blood cells of an Rh+ baby, leading to hemolysis. In contrast, transfusing Rh- blood to an Rh+ recipient is generally safe because the recipient's immune system is not sensitized to the Rh factor and can tolerate the anti-D antibodies present in the Rh- blood without adverse effects. The key difference lies in the mother's immune response and the context of exposure to Rh+ blood.

Nov 7, 2004

Cheman

Haemolytic disease and the rheasus blood group...

Why do you get haemolytic disease in a baby ( not first baby) if the mother is Rh- and her anti D antibodies cross the placenta, yet it is fine to tranfuse Rh- blood to a Rh+ recipient, which will also contain anti D antibodies?

Thanks in advance.

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Nov 7, 2004

Cheman

I've just noticed there is a slight flaw in my question 4get it.

Sorry.

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