Holding Your Breath and Brain Damage

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Holding your breath can lead to serious consequences for brain function, with permanent damage potentially occurring after just three minutes of apnea. Most individuals will faint and resume breathing involuntarily before reaching this critical point. The inability to breathe causes carbon dioxide to accumulate in the blood, leading to a dangerous drop in pH and stimulating the brain's respiratory center. Generally, after 5 to 10 minutes without breathing, the risk of severe and irreversible brain damage increases significantly. However, under specific conditions like hypothermia, individuals—particularly children—may survive longer periods without lasting harm, as lower body temperatures can slow metabolism and reduce damage. This phenomenon is sometimes referred to as suspended animation, which has been explored in research contexts, although some studies have faced withdrawal.
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How long would it take for your brain to be permanently damaged after holding your breath? In other words, after how long of holding your breath will your brain function be at risk?

A quick Google search gave me varied results. :confused:
 
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Julio R said:
How long would it take for your brain to be permanently damaged after holding your breath? In other words, after how long of holding your breath will your brain function be at risk?

A quick Google search gave me varied results. :confused:

You will most probably faint before causing any damage and start breathing again sub-consciously.
but still:
wiki said:
Prolonged apnea leads to severe lack of oxygen in the blood circulation. Permanent brain damage can occur after as little as three minutes and death will inevitably ensue after a few more minutes unless ventilation is restored. However, under special circumstances such as hypothermia, hyperbaric oxygenation, apneic oxygenation (see below), or extracorporeal membrane oxygenation, much longer periods of apnea may be tolerated without severe consequences.
Untrained humans cannot sustain voluntary apnea for more than one or two minutes[citation needed]. The reason for the time limit of voluntary apnea is that the rate of breathing and the volume of each breath are tightly regulated to maintain constant values of CO2 tension and pH of the blood. In apnea, CO2 is not removed through the lungs and accumulates in the blood. The consequent rise in CO2 tension and drop in pH result in stimulation of the respiratory centre in the brain which eventually cannot be overcome voluntarily.
 
After 5 to 10 minutes of not breathing, you are likely to create serious and probably permanent brain damage.
The one exemption is when a young person stops breathing and also becomes abnormally cool at the same time. This can happen when a kid is instantly plunged into very cold water and drowns. In this scenario, survival after more than 30 minutes has been known to occur.
 
paulmarin said:
The one exemption is when a young person stops breathing and also becomes abnormally cool at the same time. This can happen when a kid is instantly plunged into very cold water and drowns. In this scenario, survival after more than 30 minutes has been known to occur.

How can this occur ?
 
Both act to slow down metabolism so less damage occurs. The state is called suspended animation. Last time I heard about it, they were using hydrogen sulfide which has a similar effect to not breathing (it blocks oxygen). The studies were in trials, but the trials got withdrawn in 2011.
 
Pythagorean said:
Both act to slow down metabolism so less damage occurs. The state is called suspended animation. Last time I heard about it, they were using hydrogen sulfide which has a similar effect to not breathing (it blocks oxygen). The studies were in trials, but the trials got withdrawn in 2011.

I think they used suspended animation to operate on baby mice during regenerating research. It put them in a" dead-like" state.
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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