Medical How close are we to genetically altering brain functionality?

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The discussion centers on the feasibility of genetically enhancing human brain functions such as memory and processing speed. Participants express skepticism about the current state of genetic research, emphasizing the need for a profound understanding of brain mechanisms before any advancements can be made. Concerns are raised about the complexities of gene interactions and the risks associated with gene therapy, citing past failures where poorly tested therapies resulted in severe consequences. While there is acknowledgment of the potential within the human genome, the consensus is that significant breakthroughs are not imminent. Suggestions for improving memory through methods like the dual n-back game are mentioned, but interest in such activities appears low among participants.
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Title says it all. How close are we to genetically instilling more memory, faster processing power, etc.. in the human brain?

Can an admin please PM this time before just deleting the thread? It's a serious question and an interesting discussion if taken as such.
 
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thehacker3 said:
Title says it all. How close are we to genetically instilling more memory, faster processing power, etc.. in the human brain?

Can an admin please PM this time before just deleting the thread? It's a serious question and an interesting discussion if taken as such.

Not close at all... remember that to achieve those ends we need to have a deep understanding of memory and what makes the brain work "faster" and "better". The last time gene therapy was tried with good intentions and little testing, it killed all save one participant.

I would say we're not even within sight of such a breakthrough, unless it came out of nowhere. Remember that genes act in an incredibly complex fashion with each other, the environment, and then each other again. It's one thing to make a fern bioluminescent, quite another to enhance a brain without killing it.
 
nismaratwork said:
Not close at all... remember that to achieve those ends we need to have a deep understanding of memory and what makes the brain work "faster" and "better". The last time gene therapy was tried with good intentions and little testing, it killed all save one participant.

I would say we're not even within sight of such a breakthrough, unless it came out of nowhere. Remember that genes act in an incredibly complex fashion with each other, the environment, and then each other again. It's one thing to make a fern bioluminescent, quite another to enhance a brain without killing it.

Thank you for a much more informative response. This answered my question quite well, actually.
 
thehacker3 said:
Thank you for a much more informative response. This answered my question quite well, actually.

Glad to hear it, and if you're intersted (which it seems you are), I'd begin by researching gene therapy over the past decade or two, the expecations for it at the outset, and the reality.

There is a lot of promise in our genome, and altering it, but first we need to understand it... and we don't... not even close.
 
Proton Soup said:
you could try the dual n-back method to increase working memory.

http://en.wikipedia.org/wiki/N-back#Dual_n-back

i downloaded the brain workshop game, but just never seem to find the interest to play it.

My college statistics professor directed us to that game.

Agreed, no interest to play it, even if it may increase working memory.
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom

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