To calculate resistance in a circuit, use the formula I = V / R, where I is current, V is voltage, and R is resistance. The Loop Method is essential for determining voltage drops across resistors, ensuring that the sum of these drops equals zero in any loop. After calculating the voltage for each resistor, users can find missing voltages by setting up equations based on loop sums. The final resistance can be determined by subtracting voltages across resistors experiencing different potentials and applying the V = IR formula. This approach leads to a calculated resistance of 18 Ohms.