How Does Cis-Platin Affect DNA Replication?

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The discussion centers on the effects of mechloroethamine and cisplatin on DNA replication. Mechloroethamine is recognized for its role in holding DNA strands together, thereby preventing the DNA helix from unwinding, which disrupts the initial stage of replication. In contrast, the mechanism of cisplatin is less clear, particularly regarding its interaction with guanine and cytosine. Typically, guanine forms three hydrogen bonds with cytosine, but in the presence of cisplatin, it appears to form only one hydrogen bond. The inquiry seeks clarification on how cisplatin alters this bonding and impacts DNA replication. A linked resource is provided for further understanding of cisplatin's mechanism of action.
elemis
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Before I ask my question, I would like to state that I am not a Biology student. I am actually a Chemistry student who has a small section on Biochemistry in his syllabus.

Now, my problem lies with part (ii).

Mechloroethamine obviously hold the DNA strands together and prevents the DNA helix from uncurling/unzipping. Hence, the very first stage in replication is impeded.

How cis-platin affects DNA replication is eluding me. I know that Guanine normally forms 3 hydrogen bonds with Cytosine. However, it seems to be forming only one hydrogen bond in this case.

Could someone prod me in the correct direction ?
 

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