Transistors operate using semiconductors, primarily silicon, which are doped to create regions with excess electrons (n-type) or holes (p-type). The movement of electrons and holes is governed by quantum mechanics, as electrons are trapped in a crystal lattice and can only occupy discrete energy states in defined bands. When a voltage is applied, the potential difference allows for control over current flow, effectively enabling transistors to amplify signals. The concept of "holes" as positive charges is a quantum mechanical interpretation that explains observable phenomena like the Hall effect, despite the actual movement being due to electrons. Understanding these principles is crucial for grasping the relationship between transistors and quantum mechanics.