Mixing matter with antimatter leads to annihilation, which releases energy according to the equation E=mc², but does not require energy to initiate the mixing. The challenge lies not in bringing matter and antimatter together, but in preventing them from coming into contact, as they will naturally attract due to opposite charges. To keep antimatter isolated from matter, energy is needed to create containment systems, such as magnetic bottles. These systems are essential to prevent spontaneous annihilation upon contact. Thus, while annihilation itself releases energy, significant energy is required to maintain the separation of matter and antimatter.