To find the unknown in the cubic equation x^3 + x^2 + ax - 72 given that x + 3 is a factor, it is essential to ensure that F(-3) equals zero. If F(-3) does not equal zero, it indicates a miscalculation or misunderstanding of the relationship between roots and coefficients. Using synthetic division or polynomial long division can help deduce the value of 'a' by simplifying the equation. Substituting x = -3 into the equation can also provide a direct method to solve for 'a'. Understanding these mathematical principles is crucial for correctly identifying the unknown.