Medical How Well Is the Human Interferon Pathway Understood in the Immune System?

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The discussion focuses on the understanding of human interferon pathways and their regulatory mechanisms from gene to protein levels within the immune system. Participants seek reviews on the natural regulation of interferons, emphasizing their role beyond pharmaceutical applications. A notable point raised is the induction of p53, which is recognized as a significant factor in cancer suppression linked to interferon activity. The conversation questions whether p53 induction is the sole mechanism of interferon action in cancer treatment or if there are additional pathways involved.
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How well is the human interferon pathways and exact function in the immune system known, and how well is the and regulatory system from gene to protein level known?

If anyone has any pointers to reviews of the interferons in the contact of immune system and in particular what regulates it naturally (assuming it's not given as drugs).

/Fredrik
 
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It seems p53 induction is thought to be one key point in the context of cancer suppression.

Used as a cancer-drug, is p53 induction the presume only point, or are there additional points of the interferon?

/Fredrik
 

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