As near as I can tell, the Newtonian case has 3 basis vectors, time isn't handled explicitly (it is assumed to be separate from space, and handled as what is usually called absolute time, which is the usual Newtonian way of handling time).
Another important difference is the treatment of gravity, as the PSSC film quoted by bcrowell mentions, (I think bcrowell's book does too).
in the Newtonian case a frame fixed to a non-rotating Earth would be considered to be inertial, while in the GR case the frame anchored to the non-rotating Earth would be considered non-inertial, and inertial frame would be free-falling.