The antiderivative of 2 sin(2x) is -cos(2x) because when differentiating -cos(2x), the chain rule introduces a factor of 2, resulting in 2 sin(2x). The constant 2 is accounted for in the differentiation process, effectively "disappearing" during integration. Similarly, for the antiderivative of 5e^(5t), the derivative of e^(5t) yields 5e^(5t), leading to the simplification of the antiderivative to e^(5t) after dividing by 5. It is essential to remember that the antiderivative is the inverse of the derivative, impacting constants and coefficients accordingly. Understanding these relationships clarifies the confusion surrounding antiderivatives.