I have an interest in this as well, I am digging into why histamine is created, and is released in the first place. I said recently in another thread there appears to be at least 5 types of receptor sites in in the brain that either promote (neuro-transmitter) or inhibit (neuro-inhibitor) the release of histamine in the body. I find it interesting that the neuroscientific community keeps finding more and more receptor sites.
Obviously, with so many receptor sites in the brain, they are important to our health. I have a whole bunch of links I am trying to organize and construct a time-line history if you will of this stuff. As most of you familiar faces here know by now, simply treating the fact that you get an allergic reaction when you body is assaulted by chemicals, pollen, or other irritants, is not enough for me. I get motivated to try to isolate (at least for myself) the "root cause or causes" as to what can be done to keep it from limiting my normal routine (as Astronuc describes in
https://www.physicsforums.com/showpost.php?p=2866808&postcount=4" above)
I spent about a year and a half doing inhalation therapy where I'd have to inhale a vapor and lie on an incline while some pounded on my back in order to get the phelgm/mucus out of my lungs. Coughing up thick brown stuff wasn't much fun.
Ultimately I was put on allergy shots - weekly for several months, then monthly, then quarterly. After 4 years I was off the allergy shots, except perhaps once or twice in 9th grade. But by 10th grade, my lungs were clear and I could go out for sports.
I don't like to accept the status quo without first putting up a good fight, to find a treatment that hopefully is safe. One that does not have side effects worse than what the allergies are causing. That is just me. I realize this approach is not for everyone.
A perfect example would be my wife's blood pressure meds a few years ago, every winter for two years she would get a tickle that made her cough constantly. She wasn't sleeping through the night. I asked her about it a few times, but she shrugged it off (I didn't know her Dr had switched her medication). Finally, after finding she had switched meds, I spoke to a nurse friend, told her what she was taking and at the same time looked up the side effects on respectable medical sites on the net. Low and behold her advice and what I found matched, chronic cough, and drip could result, if left untreated for years, the bronchial tubes actually thicken, and become more sensitive, which I believe happened in her case, a vicious cycle if you will. She switched meds and in a short time the cough and drip almost went away, a good thing.
This is to illustrate how tolerant some are to being made uncomfortable, while others take a more proactive approach.
Rhody...