Work is considered negative when the force applied is in the opposite direction of the motion, indicating that the system is doing the work rather than the external environment. The formula for work, W = -∫PdV, highlights that positive work occurs when the environment does work on the system, while negative work occurs when the system performs work on itself. In a quasistatic constant pressure process, if the system expands (Vb > Va), it does negative work, while if it contracts (Vb < Va), the environment does positive work on the system. Practical examples illustrate this concept, such as lifting a book (positive work) versus catching a ball (negative work). Understanding these principles clarifies the distinction between work done by and on a system.