To separate a multivariable differential equation, assume the solution can be expressed as a product of two functions, one dependent on r and the other on θ, such as u(r, θ) = R(r)·Θ(θ). By substituting this into the differential equation, derivatives with respect to r will only affect R(r) and those with respect to θ will only affect Θ(θ). Rearranging the equation allows it to be expressed in a form where one side is independent of θ and the other of r, leading to the conclusion that both sides must equal a constant. This results in two independent differential equations, each with a single variable. The separation of variables method is applicable in specific cases, and once the equations are derived, techniques like Cauchy-Euler can be employed for solutions.