Controlling a large number of relays, such as 100, can be efficiently managed without requiring 100 I/O ports by utilizing I/O expanders, particularly through serial interfaces like I2C. This method allows multiple expander modules to be addressed individually by a master microcontroller, enabling control over numerous I/O ports with minimal wiring. Alternative solutions discussed include using analog switches or FETs instead of relays for their compactness, especially when voltage isolation is not necessary. Strategies for managing the relays include using universal demultiplexers, arrays of shift registers, or 2D arrays, each with its own advantages and trade-offs in terms of cost and complexity. The conversation also highlights the importance of understanding circuit requirements and PCB layout recommendations to ensure proper functionality. Additionally, considerations about the power supply and relay specifications are crucial for effective implementation.