MCQ-Effect of a scaffolding protein on Signaling

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In summary, the conversation discusses the role of scaffolding proteins in signal transduction and how they can affect the speed and efficiency of the process. A and D are both correct, while B and C are incorrect. The correct understanding is that when kinases are bound to a scaffolding protein, they are able to activate more molecules of MEK compared to when they are freely diffusing. This is because the scaffolding protein brings them into close proximity and proper orientation, allowing for faster and more efficient signal transduction.
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TytoAlba95
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My understanding:
A) As in RTK signalling in which Raf-MEK-ERK are bound to KSR, they are close enough and in proper orientations to transduce the signal faster than when they are not in a complex. So A is correct.
B) Correct. Because to cross-link with other signalling pathways the kinases have to dissociate first, which is not happening in this case.
C) I don't understand how being associated or not associated with a scaffolding protein might influence signal amplification.
D) This statement is the opposite of B and is correct, and in this case, the kinases are free to interact with other signalling proteins.

The correct answer is C.
 
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C is the correct answer.

To understand why C is not true, consider the Raf-MEK-ERK cascade. If these three kinases are scaffolded together, how many molecules of MEK will a single Raf kinase be able to activate? If these three kinases are freely diffusing, how many molecules of MEK will a single Raf kinase be able to activate?
 
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Ygggdrasil said:
To understand why C is not true, consider the Raf-MEK-ERK cascade. If these three kinases are scaffolded together, how many molecules of MEK will a single Raf kinase be able to activate? If these three kinases are freely diffusing, how many molecules of MEK will a single Raf kinase be able to activate?

Wow! You put it so simply. You truly are a great teacher. : )
 
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1. What is a scaffolding protein?

A scaffolding protein is a type of protein that serves as a structural support for other proteins in a cell. It acts as a framework or scaffold, bringing together different proteins involved in a specific signaling pathway.

2. How does a scaffolding protein affect signaling?

A scaffolding protein can affect signaling in several ways. It can physically bring together different proteins, allowing for more efficient and coordinated signaling. It can also regulate the activity of specific proteins in the pathway, ensuring proper timing and intensity of the signal. Additionally, scaffolding proteins can act as a platform for the formation of signaling complexes, which can enhance the specificity and accuracy of signaling.

3. What are the benefits of using scaffolding proteins in signaling?

Using scaffolding proteins in signaling can provide several benefits. It can increase the speed and efficiency of signaling, as well as improve the accuracy and specificity of the signal. Scaffolding proteins can also help to prevent crosstalk between different signaling pathways, ensuring that each pathway is functioning properly.

4. Are scaffolding proteins essential for signaling?

No, scaffolding proteins are not essential for signaling. However, they can greatly enhance the efficiency and accuracy of signaling. In some cases, scaffolding proteins may be necessary for the proper functioning of a specific signaling pathway.

5. How do scaffolding proteins differ from other types of proteins involved in signaling?

Scaffolding proteins differ from other types of proteins involved in signaling in that they do not directly participate in the signaling process. Instead, they act as a support or organizer for other proteins involved in the pathway. Scaffolding proteins also tend to have multiple binding sites, allowing them to interact with and bring together multiple proteins involved in the pathway.

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