More observed Beta sheets than Alpha helices as temperature increases

AI Thread Summary
As temperature increases, alpha helices are less stable due to the breaking of hydrogen bonds, leading to a higher prevalence of beta sheets. The hydrophobic effect may play a role in this transition, but its exact influence on structural formation remains unclear. The discussion highlights a lack of context regarding the experimental methods used in the study, making it difficult to draw definitive conclusions. Participants express uncertainty about the reasons behind the observed structural changes. Further investigation into the specific experimental conditions is necessary to understand the phenomenon better.
Ran4
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From an experimental study I've found that alpha helices are formed more often than beta sheets when the temperature is low, but when the temperature increases the beta sheets becomes more common. I'm trying to figure out why.

As temperature increases, the outer hydrogen bonds of a structure will start to break, which will increase the hydrophobic effect, but how does that make beta sheets more common? Or is that not relevant in deciding which structure is most likely to form?
 
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Ran4 said:
From an experimental study I've found that alpha helices are formed more often than beta sheets when the temperature is low, but when the temperature increases the beta sheets becomes more common. I'm trying to figure out why.

As temperature increases, the outer hydrogen bonds of a structure will start to break, which will increase the hydrophobic effect, but how does that make beta sheets more common? Or is that not relevant in deciding which structure is most likely to form?

I doubt I could be the one to answer this but here is just no context provoded for anyone to answer except by guessing what you are talking about. Experimental study of exactly what by what methods?
 


epenguin said:
I doubt I could be the one to answer this but here is just no context provoded for anyone to answer except by guessing what you are talking about. Experimental study of exactly what by what methods?

I don't know. The goal of the task is to just find some reason as to why beta sheets are more common at higher temperatures. There is very little information given.
 
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