To solve the equation n^5 + 80 = 5n^4 + 16n, factoring is a recommended approach, particularly by guessing integer roots. The roots identified are n = 5, 2, and -2, which can be found by rearranging the equation to n^5 - 5n^4 - 16n + 80 = 0. Factoring leads to the expression (n^4 - 16)(n - 5) = 0, allowing for the determination of roots as n = ±2 and n = 5. Synthetic division and factoring by grouping are also effective methods for solving such polynomial equations. The discussion highlights the importance of recognizing patterns and relationships in the coefficients for successful factorization.