One fluid forcing another out in a microchannel

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In microfluidics, a microchannel filled with fluid 1 is being displaced by fluid 2 under a constant pressure drop. The challenge is to determine the pressure at the interface between the two fluids, given the volumetric flow rate, viscosity, and total pressure drop. The flow is assumed to be laminar and viscous, with no stratification or annular core formation. The discussion suggests that while the interface is constrained by channel walls, Laplace's equation can be applied to find the pressure jump across the interface based on its curvature. Resources for solving such problems in microchannels are sought to better understand the dynamics involved.
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Hi

I'm currently doing some work in microfluidics on a microchannel device. This microchannel has a known, constant pressure drop across it and is initially filled up with fluid 1. Fluid 2 then is allowed to flow into the channel, "pushing" fluid 1 out.

What I'd like to know is how to go about finding the pressure at the interface between fluid 1 and 2. I know the volumetric flow rate Q, one of the viscosities, and the total pressure drop across the channel.

The microchannel is rectangular and leads to a solution of:

Q=\alpha \frac{1}{\mu}\frac{dp}{dx} with mu as viscosity and alpha as some geometric factor.

However, this is for a single fluid in a microchannel of constant length. In my situation, the effective length for each fluid gets larger or small as fluid 2 pushes out fluid 1. Do I need to treat the entire microchannel as one system whose density is changing (as fluid 2 replaces fluid 1), or can I cobble together two of the time-independent solutions for each fluid?

Could someone point out some resources for this type of problem? I am assuming the flow is laminar viscous and doesn't become stratified or form an annular core. Thanks!
 
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Because your interface is constrained by the channel walls, the precise determination will be difficult. However, Laplace's equation \Delta P = -2\sigma\kappa is still valid- the pressure jump across an interface is given by the curvature of the interface.
 
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