The discussion centers on whether space can be considered "full" of photons, given that they have no mass. While photons exist in various forms of radiation throughout space, their presence does not negate the definition of a vacuum, which is based on the absence of matter. Photons, being bosons, can occupy the same space without filling it, unlike matter, which consists of fermions that take up space. The conversation also touches on neutrinos, which are neutral particles that rarely interact with matter but can fill space if manipulated. Ultimately, the concept of a vacuum remains tied to matter density rather than the presence of photons.