Proteases and glycosidases differ significantly in their substrate specificity and function. Glycosidases are primarily involved in the degradation of sugars and exhibit high specificity, often acting on one substrate. In contrast, proteases break down proteins and can have a broader spectrum of activity, potentially compensating for deficiencies in specific proteases. This distinction is particularly relevant in the context of lysosomal storage diseases, which are mainly caused by deficiencies in glycosidase enzymes rather than proteases. The discussion highlights the importance of enzyme specificity in the context of metabolic disorders.