The discussion centers on the probability of inhaling a volume of air devoid of oxygen, which constitutes about 20% of air molecules. Participants explore the mathematical approach to calculate this probability, initially suggesting the use of a Poisson distribution to model the number of oxygen molecules in a person's lung volume. The formula for the number density of air molecules is introduced, relying on atmospheric pressure and temperature. However, it is noted that from a biological perspective, the probability of completely emptying the lungs of air is effectively zero, as some oxygen always remains after exhalation. The conversation shifts to the binomial distribution as a potentially simpler method for calculating the probability, with participants acknowledging the complexity of the problem and its relevance to understanding statistical mechanics and orders of magnitude in real-world scenarios. Overall, the discussion highlights the interplay between mathematical modeling and biological realities in assessing the likelihood of inhaling air without oxygen.