Resistors are in series if the current flows through one resistor and must continue to the next without branching. In contrast, resistors are in parallel if the current can choose between multiple paths to reach the resistors. The total resistance in a series circuit is greater than any individual resistor, while in parallel, it is less than the smallest resistor. The configuration can be visually identified by examining the connections between terminals. Understanding these principles is essential for analyzing series/parallel circuits effectively.