Hi, photonist,
Welcome to PF!
Cool idea! However, I don't think the nuclear-physics application is right.
Fist off, the mass parameter is not going to be the mass defect. This kind of thing is generically known as an "inertial parameter" in nuclear physics, and it is very difficult to calculate. There are various approximations that can be written down for them, based on, e.g., low-amplitude oscillations of a classical, nonviscous liquid drop. But in reality, these approximations are only good to within about an order of magnitude. One reason is that nuclei are superfluid in the ground states. The only thing that really *is* straightforward to calculate is the inertial parameter after scission, which is just what you would expect classically for two separate bodies.
In the case of spontaneous fission, the order-of-magnitude theoretical uncertainty in the inertial parameter swamps any relativistic corrections. The relativistic corrections are quite small, since the fragments are not highly relativistic.
In addition, the anharmonicities are huge, especially when you're talking about fission (as opposed to a simple vibration of the nuclear shape about its equilibrium). Also it's a quantum-mechanical system, not a classical one. And nuclear vibrations at small amplitudes are typically not very highly collective, which means that it isn't really very accurate to think of them as pure shape oscillations; they're more like somewhat coherent superpositions of some small number of different single-particle excitations.
-Ben