The simplest method (not necessarily the most expedient or most elegant) is simply to plot points and connect the dots. That is, pick a value for x, find the corresponding value(s) for y. Plot them on the graph, then connect the dots. That's basically what a graphing calculator does, btw
For rational functions, there are ways to be much more elegant. Finding horizontal/oblique and vertical asymptotes saves much work (From this point on I'm going to ignore oblique asymptotes, because they only exist when a horizontal asymptote is missing, and the process for dealing with them is virtually the same). Determining whether and where your curve crosses the horizontal asymptote can give you a lot of information. Once you find the vertical asymptotes and the points where the curve crosses the horizontal asymptote, you can test each region of your domain for whether the curve is above or below the horizontal asymptote. Since you can't cross the vertical asymptotes or the horizontal asymptote besides the point(s) you found, the rest of the curve should be fairly easy to sketch.
Another thing that can make your sketch easier is finding the zeros. What values of x can you plug in that will make y=0? If you have a rational function, those zeros can do double duty, helping you determine whether you are above or below (or crossing) your horizontal asymptote.
When you have square roots involved, you will need to find the domain. Aside from finding the zeros, I can't think of anything else you can use to simplify the sketching process in that case.
If all else fails and you can't remember any special technique, you can always go back to plotting points, as I mentioned at the beginning of this post.