The discussion centers around a spool error message encountered in Windows ME, which leads to application failures and system hangs. A common cause identified is a compatibility issue with antivirus programs, particularly those that operate as TSR (Terminate and Stay Resident) applications, which conflict with the Windows spooler. To resolve the issue, users are advised to adjust printer properties by changing the spool settings to print after the last page has spooled. Additionally, there are suggestions to upgrade to Windows 2000 or XP for better stability, as Windows ME is considered outdated and problematic. Concerns about faulty RAM are also mentioned as a possible cause of frequent application and OS failures.