To determine if an integrated circuit (IC) is functional, start by measuring the voltage on each pin and comparing it to the expected values from the datasheet. It’s crucial to check power pins first and ensure that you don’t short any pins while measuring. If most pins show the same voltage or the IC is excessively hot or cold, it may indicate a problem. ICs are generally reliable, so consider checking other components like electrolytic capacitors before replacing the IC itself. Utilizing a test circuit from the datasheet can also help verify the IC's functionality.