A coworker played a prank by taking a screenshot of another's desktop, setting it as the background, and hiding the icons, which led to confusion before it was discovered. The discussion revolves around ideas for payback, with suggestions including minor annoyances like inserting paper into keyboard USB ports, swapping keyboard keys, and changing mouse button functions. More elaborate pranks mentioned include setting the computer to a humorous website while hiding the keyboard and mouse, and using keyboard shortcuts to flip the screen orientation. The conversation highlights the playful nature of office pranks and the creativity involved in retaliatory actions.