Trigonometric substitution involves replacing a variable in an integral with a trigonometric function, such as x = sin(u) or x = tan(u), to simplify the integral using trigonometric identities. After performing the substitution and integrating, the original variable is substituted back to obtain the final answer. A sample problem illustrates this process, demonstrating how to transform the integral ∫ dx/√(a² - x²) using x = a sin(θ). Participants discuss specific integrals and the simplification steps involved, emphasizing the importance of trigonometric identities in the process. The conversation highlights the challenges and solutions encountered while working through calculus problems.