Understanding the Role of Erythropoietin in Red Blood Cell Production

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Erythropoietin (EPO) is a hormone produced by the kidneys in response to low oxygen levels in the blood. Its primary role in erythropoiesis, the process of red blood cell (RBC) production, involves stimulating the synthesis of mRNA, which is essential for the production of proteins necessary for RBC formation. This stimulation accelerates all stages of erythropoiesis, leading to an increased number of RBCs. Additionally, EPO reduces the maturation time of RBCs in the bone marrow, allowing for a quicker release of fully developed cells into the bloodstream. This mechanism helps to restore adequate oxygen levels in the body. EPO has also been misused by athletes to enhance performance by increasing RBC count.
Asmaa Mohammad
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Hi,

I don't actually get the function of erythropoitin hormone in erythropoiesis, what is written in my textbook is that erythropoietin accelerates all steps of erythropoiesis as it stimulates mRNA synthysis, and also, it shortens the maturation time of RBCs in the bone marrow.

I would like a simple explanation on the basis of medical physiology.

Thanks in advance!
 
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Erythropoietin is released from cells in the kidney when they sense low oxygen.
Erythropoietin stimulates red blood cell production, thus correcting a possible cause of low blood oxygen by triggering the making of more red blood cells.

It has also been used by athletes to gain an advantage in races etc.
 
Hmm, sorry but still I don't understand the part of mRNA synthysis and short maturation period in the main passage I wrote in #1. Could you explain it for me, please?
 

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