Lapidus said:
How do we explain physically interactions? Interactions that respect relativity (a local theory) and quantum theory.
1. What happens at the time when two high energy particles scatter off each other?
What happens between the measurements of in and out states in high energy experiments?
2. How do two like charges repel? How do two charges interact?
3. What happens physically at very short distances and very short times when particles interact, i.e. are created and destroyed?
4. What forbids 'virtual'/ 'off-shell' particles from forming, despite that they are a logical consequence from quantum uncertainty and Einstein's momentum-energy relation?
How are physical explanations of quantum relativistic interactions (interactions in our Universe, that is) without 'virtual' states possible?
I'll try to show you my point of view trough a classical physics example.
Suppose to have a charge distribution \rho(x) and a test charge scattering from it.
You can decide to decompose the cross section in many ways.
One option is to use a multi-pole sum to describe \rho(x) and then sum the various contributes. This could be very useful because at long distances from the charge distribution the main contribution to the cross section is due to the first non trivial multi-pole term (for example usually a dipole for a neutral atom).
Obviously we could instead simply decide to calculate the full electromagnetic field of \rho(x) and compute the exact cross section all at once. It's generally too difficult to do, but still if we would be good enough with math it would be a possibility, and for some charge distributions we actually do this.
If the second option is used, then there are no multipoles in our description but we can still see the test charge scattering.
This is very close to what happens in QFT: we decompose the scattering amplitude in contributions due to different virtual particles exchange. It's useful because at low energies only the lowest non trivial terms contributes to the cross section.
We could (if we only could solve exactly the equations, or even with some mean field approximation) describe the scattering between two charges without the use virtual photons. Obviously there would still be the electromagnetic field mediating the interaction, but no virtual particles would appears.
Ilm
PS I'd like to point out that the usual definition of particles as asymptotic states of non interacting fields is ill defined, what we call electron for example is not only an excitation of the electronic field but contains all other fields also (for example a lepton could very weakly interact via strong interaction).