Centimeter squared (cm²) represents an area measurement, indicating a square with each side measuring one centimeter. Conversely, centimeter cubed (cm³) denotes a volume measurement, representing a cube with each side also measuring one centimeter. For example, a square with sides of 5 cm has an area of 25 cm², while a cube with the same side length has a volume of 125 cm³. The distinction between area and volume is crucial, as cm² measures two-dimensional space, while cm³ measures three-dimensional space. Understanding these concepts is essential for accurate calculations in geometry and physics.