What does one carbon metabolism of folic acid mean?

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The discussion centers on the concept of a "1-carbon unit" in biochemical processes, specifically in relation to folic acid (tetrahydrofolate). A 1-carbon unit can refer to various forms, including methyl, methylene, or formate, which are involved in biosynthetic pathways. The transfer of these units contributes to the synthesis of important compounds. For example, formate can be sourced from the solution, while methyl groups are derived from the amino acid serine. The conversion processes include the transformation of methyl-substituted tetrahydrofolate to methylene-substituted tetrahydrofolate through oxidation involving NADP+. These reactions illustrate the significance of 1-carbon units in metabolic pathways.
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What does that mean. Transfer of 1-carbon unit. What is a 1-carbon unit, are they referring to carbon number 1(according to nomenclature) of the molecule being transferred or a single carbon atom from the molecule is transferred? Can anyone explain. Thanks :smile:
 
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sameeralord said:
What does that mean. Transfer of 1-carbon unit. What is a 1-carbon unit, are they referring to carbon number 1(according to nomenclature) of the molecule being transferred or a single carbon atom from the molecule is transferred? Can anyone explain. Thanks :smile:

The one carbon unit in this case can be methyl, methylene or formate. It adds to the molecule of "folic acid" (actually tetrahydrofolate) and thereafter is donated in various biosynthetic pathways. Formate (a one carbon species) is available from the solution but the methyl is donated by serine, an amino acid. Methylene-substituted tetrahydrofolate is produced from the methyl-substituted tetrahydrofolate by an oxidative process involving NADP+.

Formate + tetrahydrofolate ------> formyltetrahydrofolate

Serine + tetrahdyrofolate -------> methylenetetrahydrofolate + glycine

methylenetetrahydrofolate --------> methenyltetrahydrofolate
 
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