Wire ORing an output refers to connecting multiple comparator outputs together, allowing any active signal from either output to create a combined signal. This technique is based on the logical OR function, where the presence of a signal on either wire results in a signal at the joined output. It's important that the outputs being combined are not adversely affected by being forced high. The discussion specifically mentions the uA311 precision comparator in this context. Understanding this concept is crucial for implementing effective circuit designs.