What is Coupled Phosphorylation?

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Coupled phosphorylation refers to the process where the phosphorylation of proteins, particularly enzymes, regulates metabolic pathways. In this context, phosphorylation typically inactivates enzymes, leading to a shutdown of specific metabolic pathways, known as a phosphorylation cascade. Conversely, dephosphorylation reactivates these enzymes, reinitiating the metabolic processes. Additionally, receptor sites on cell membranes can respond to external hormones or hormone mimics, influencing these cascades. For instance, hormones like glucagon and adrenaline can trigger a phosphorylation cascade that inhibits glycolysis. This interplay between phosphorylation and dephosphorylation is crucial for cellular regulation and metabolic control.
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"Coupled Phosphorylation"

For school I am being forced to read SIlent Spring by Rachel Carson(which bores me to death, but anyways...) The author goes into very little detail on what coupled phosphorylation means, which is confuusing me every time she brings it up...Any helpon what this is...?
 
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The book is 40+ years old, I believe what is referred to is the fact that phosphorylation of proteins (specifically enzymes) turns off the metabolic pathway they are active in - this is called a phosphorylation cascade.

The opposite effect, dephosphorylation, switches the enzymes activity back on - turning on the metabolic pathway.

Receptor sites on cell membranes respond to external hormones or hormone mimics like some chlorinated compounds either turning on a cascade or turning it off. glucagon and adrenaline turn on a p-cascade that shuts down glycolysis, for example.
 

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