Nuclear fission involves the splitting of heavy atomic nuclei, such as Uranium-235, into smaller, radioactive nuclei, releasing energy through neutron collisions. In contrast, nuclear fusion combines light atomic nuclei, like deuterium and tritium, to form a larger, more stable nucleus, such as helium, requiring high temperatures to overcome the Coulomb force. Fission can occur at room temperature under the right conditions, while fusion requires extreme conditions to initiate. Additionally, there is speculation about low energy nuclear reactions (LENR), which involve medium atomic number isotopes, but these remain largely theoretical and unproven. Understanding these differences is crucial for grasping the fundamentals of nuclear science.