What is the origin of plasmids?

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Plasmids are autonomous units of DNA that replicate independently within bacterial cells, similar to mitochondria, but they are not classified as life forms. They are transferred between bacteria through a process called conjugation and are considered "naked" DNA. The discussion raises questions about the origins of plasmids, particularly how the first plasmid entered the first bacterium, suggesting possibilities such as phagocytosis of a virus or another prokaryotic cell with circular DNA. The conversation also touches on the evolving definitions of life, referencing discoveries of mega-viruses and the complex relationships in organisms like lichens, which may illustrate a trend towards symbiosis and genetic simplification.
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As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
 
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jaumzaum said:
As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
Originally from another prokaryote I would have thought as per the mitochondria
 
jaumzaum said:
As I understand it, plasmids, like mitochondria, have their own genetic material and are capable of self-replication.

According to Wikipedia: Plasmids are considered replicons, units of DNA capable of replicating autonomously within a suitable host. However, like viruses, they are not classified as life. Plasmids are transmitted from one bacterium to another through conjugation. Unlike viruses, plasmids are "naked" DNA. However, some classes of plasmids encode the conjugative "sex" pilus necessary for their own transfer.

My understanding of that is that a bacteria gets their plasmids not because of the replication of their circular chromosome, nor because that chromosome have genes to code for the plasmid (I don't really know if that's possible), but because of the self-replication of their own plasmids.

So, my question is how the first plasmid got into the first bacteria, if they are not in their chromosomes? Were they a virus other prokaryotic cell that had circular DNA, and got phagocytosed by that bacteria ?
A quick search has given me a few things but they are quite old.
One from Leeuwenhoek 1998
What have you found?
 
IMHO, the recent discovery of mega-viruses, including some with size and/or genetics bigger than small bacteria, suggests 'Life' definition needs to be loosened.

Is pollen alive ? Not without a female flower. So, akin to a virus or phage...
Spores ? Yes, as self contained...

Tricky.
Looks like the origins of 'life as we know it' were even more of a 'free for all' orgy than 'tis yet comfortable to admit.

Modern parallel may be 'lichen', which is, wiki-quote, 'a composite organism that emerges from algae or cyanobacteria living among the filaments (hyphae) of the fungi in a mutually beneficial symbiotic relationship.'

IIRC, recent research suggests many lichens have a third, previously unsuspected team-member, yeast. This is also a fungi, but has evolved a rather different life-style...

Whatever, IIRC, several lichens' components seem well along to losing their independence, discarding 'surplus' genetic function, perhaps evolving towards what far future might consider akin to 'plasmids'...
;-)
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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