I think this discussion has drifted off from the question asked in the thread title (the answer to that question is: a physics experiment begins with a grant application

)
I like to think of the collapse hypothesis as having two parts:
- When you measure an observable, you get an eigenvalue (with probabilities given by the Born rule).
- Afterward, the system is in the state obtained by projecting the state onto the subspace corresponding to that eigenvalue.
(There is a sense in which rule #2 is only relevant for entangled systems. Typical measurements are destructive; when you measure a photon, the photon is gone afterward. So rule #2 comes into play when you have entangled subsystems: measuring a property of one subsystem can cause the other subsystem to "collapse" into a particular state.)
Rule #2 is definitely true, empirically, in the sense that it correctly predicts subsequent measurement results. But it's possible that it isn't necessary as an additional assumption, because you can always recast a sequence of measurements as a single, compound measurement, and so rule #1 would be sufficient. Rule #2 is more of a practical rule of thumb, because without collapse, you can't calculate probabilities for a sequence of measurements without describing the measuring devices quantum mechanically, which is infeasible. Collapse allows us to treat macroscopic measurement devices as if they were classical, having definite states at all times, and reserve QM for the description of microscopic systems (or extremely simple macroscopic systems).
To me, the weirdness of QM comes not from the collapse hypothesis, but from Rule #1. Why are observed values definite, when unobserved values are not? That seems to me to make "measurement" into a different class of interaction, but surely measurement should be explainable as quantum mechanical interactions between the system being measured and the measuring device?