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Why are Ni+2 and Cr+6 carcinogenic?

  1. Apr 19, 2012 #1
    What is the mechanism by which these cations cause cancer?
  2. jcsd
  3. Apr 20, 2012 #2


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  4. Apr 20, 2012 #3
    OK...so from this, the short answer appears to be: (1) Ni+2 catalyzes reactions that create reactive oxygen species (peroxide, superoxide). (2) inhibits excision-repair of DNA. (3) cause gene silencing (more methylation of histones, less acetylation).

    Wow, I had no idea nickel did all this...
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