Why are Ni+2 and Cr+6 carcinogenic?

  • Thread starter praeclarum
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In summary, Ni+2 and Cr+6 are considered carcinogenic because they have been found to cause cancer in various studies. This is due to their ability to form reactive oxygen species (ROS) that can damage DNA and disrupt cellular processes, leading to the development of cancerous cells. Specific types of cancer, such as lung and skin cancer, have been linked to exposure to these metals. The main sources of exposure include industrial processes and certain consumer products. While there are established safe exposure limits, any level of exposure can still pose a risk for developing cancer.
  • #1
praeclarum
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What is the mechanism by which these cations cause cancer?
 
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  • #3
OK...so from this, the short answer appears to be: (1) Ni+2 catalyzes reactions that create reactive oxygen species (peroxide, superoxide). (2) inhibits excision-repair of DNA. (3) cause gene silencing (more methylation of histones, less acetylation).

Wow, I had no idea nickel did all this...
 

1. Why are Ni+2 and Cr+6 considered carcinogenic?

Both Ni+2 and Cr+6 are known to be carcinogenic because they have been shown to cause cancer in various studies. They can damage DNA and disrupt normal cellular processes, leading to the development of cancerous cells.

2. What is the mechanism behind the carcinogenicity of Ni+2 and Cr+6?

Ni+2 and Cr+6 are able to form reactive oxygen species (ROS) which can damage DNA and other cellular components, leading to mutations and alterations in cell growth and division. This can ultimately result in the development of cancer.

3. Are there any specific types of cancer associated with Ni+2 and Cr+6 exposure?

Yes, there are specific types of cancer that have been linked to exposure to Ni+2 and Cr+6. These include lung cancer from inhalation of these metals, and various types of skin cancer from direct skin contact.

4. What are the main sources of Ni+2 and Cr+6 exposure?

Ni+2 and Cr+6 can be found in various industrial processes, such as metal plating, welding, and stainless steel production. They can also be present in certain consumer products, such as batteries and chrome-plated items.

5. Is there a safe limit for exposure to Ni+2 and Cr+6?

There are established safe exposure limits for both Ni+2 and Cr+6 set by regulatory agencies such as the Occupational Safety and Health Administration (OSHA) and the Environmental Protection Agency (EPA). However, it is important to note that any level of exposure to these metals can still pose a risk for developing cancer.

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