This *why* and the related *how* question is a difficult question. From within quantum mechanics the nearest explanation is quantum field theory. However that does not actually answer the question which is more of an ontological nature. QM is premised on particles being 0-D points with intrinsic variables, and these quantum numbers are mathematical constructs rather than physical attributes. Consequently it is unrealistic to expect explanations based on physical realism, and indeed many interpretations of QM deny physical realism altogether. So this means there is no physical answer to the questions from within QM, and possibly there never will be.
Nonetheless QM is not the only theory of physics. There are also the string theories and non-local hidden-variable (NLHV) theories, both groups of which allow particles to have internal structure. The question is more tractable within those other frameworks. A number of journal papers address this issue and qualitative explanations are available.
The explanations are given in terms of the internal rearrangement of the particle under conservation and energy laws, and the perturbation of random vacuum fluctuations, and the resulting emergence of new particle identities. The result is that the state of the particle and its external environment (bond or not, perturbation by photons, fields, or other particles) determines the hazard rate. This is the probability of the particle failing in the next time interval. Different particles have different hazard rates, and therefore show different decay half-lives. It is not helpful to think of it as involving deterministic timers. Better to think of it as the particle needing to remanufacture itself because its existing state (structure and energy) is unsuitable to the dynamic and uncertain set of external perturbations that it experiences. Related to the question about the lifetimes of particles, is the especially tough question about the stability, instability, and non-existence of nuclides, which can be addressed by NLHV theory. Why do adjacent isotopes differ so greatly in these respects? Why the different lifetimes? Why are the drip lines where they are? Why the stable isotopes and isotones? Why the gaps in the stable series? These issues are inadequately explained by empirical considerations of binding energy, or semi-empirical mass formula (SEMF), or by quantum theory.
Consequently the answer to the question depends on one's philosophical position on what comprises a sufficient theory of physics. If empiricism is the objective then quantum mechanics will give the necessary mathematical formulation of the overall probabilities of the decay transitions, and allow quantification of the effect. But don't expect explanations based on physical realism from QM because it's not that type of theory. If you wish to have physical realism then the NLHV theories may give you greater satisfaction as they can already explain these effects though as yet only qualitatively.