Assume the fusion of Deuterium (H2) and Tritium (H3) (isotopes of hydrogen having, respectively, one neutron and two neutrons). They can be fused together into a single Helium-4 atom and a free neutron.
The binding energy of Deuterium is: 2224,52±0,20 keV (Wikipedia)
The binding energy of Tritium is: 8481,821±0,004 keV (Wikipedia)
The binding energy of Helium-4 is: 28300.7 keV (Wikipedia)
The energy generated by fusion Deuterium and Tritium is therefor:
28300,7 keV - 2224,52 keV - 8481,821 keV = 17,59 MeV
http://upload.wikimedia.org/wikipedia/commons/5/53/Binding_energy_curve_-_common_isotopes.svg
In the above graph, going upward will release energy (since Ferrum-56 binds the easiest). So for lighter atoms, fusion will release energy, while for larger atoms, fission will release energy.EDIT:
Now to answer the question asked in your title: you should check the graph. Going from (any isotope of) Hydrogen to Helium (or even higher) will generally produce more energy then any kind of fission, for example that of Uranium.