Medical Why is sleep necessary for rest and rejuvenation?

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The discussion highlights the significant difference between actual sleep and mere rest. A person who sleeps for four hours experiences rejuvenation and feels refreshed upon waking, while someone who lies down but cannot sleep feels fatigued and heavy. The key distinction lies in the unconscious state of sleep, which is essential for the body to regenerate and recuperate. Important psychological and neurological processes, as well as metabolic shifts, occur only during sleep, underscoring the necessity of being in a true sleeping state for effective rest and recovery.
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Take this case:

A person sleeps for four or so hours and there's another person who lies down for four hours but he cannot sleep, yet he rests.

What's the real difference? The person who has slept feels fresh after getiing up which the other person feels heavy and fatigued. Why? Should we be unconscious to get rest?
 
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Well, in that particular case i think both would feel pretty groggy...
In general, you do need to be unconscious - and not just that, but in a sleeping state. If you're not doing anything on your computer, that doesn't mean its turned off... it just means its not actively doing anything.

For your body to regenerate/recuperate, you need to be asleep - a lot of the important effects of sleeping are psychological/neurological, and don't work when you are awake.
Similarly shifts in your metabolism, etc won't happen until you're asleep.
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom

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