The discussion focuses on solving the ordinary differential equation (O.D.E.) y' = (x^2 + y^2) / xy, which is not separable. A change of variables, specifically y = xV(x), is suggested to transform the equation into a separable form. The substitution leads to the simplified equation z' = 1/(xz), which is separable and can be solved. The solutions derived indicate that both positive and negative signs are valid, as both y and -y satisfy the original O.D.E. However, specific initial or boundary conditions would yield a unique solution.