Why doesn't decreased insulin secretion during stress cause problems?

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In fight-or-flight situations, alpha 2 receptors on pancreatic beta cells are stimulated, leading to decreased insulin production. This reduction raises blood sugar levels, which is beneficial for immediate energy needs. However, there is confusion about how decreased insulin affects glucose intake and energy production in muscle tissues, as insulin typically promotes glucose uptake and glycolysis. Despite lower insulin levels, adrenaline (epinephrine) plays a crucial role by binding to adrenergic receptors, which inhibits insulin secretion and stimulates glycogenolysis and glycolysis in muscles, ensuring energy availability. Ongoing research indicates that muscles can also increase glucose uptake through mechanisms independent of insulin, further supporting energy production during stress responses.
tarekatpf
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During fight-or-flight situations, alpha 2 receptors ( which are inhibitory receptors ) of the pancreatic beta cells are stimulated, and as a result there's decreased insulin production. While it benefits the body by producing increased blood sugar level, I don't understand why Insulin doesn't cause some problems. Such as, since insulin increases glucose intake by the muscle tissues ( skeletal muscles are supposed to be used more in flight-or-fight situations ) and increases glycolysis ( which produces energy ), wouldn't decreased insulin release during flight-or-fight situations cause less glucose intake and less glycolysis ( as a result less energy production ) by the muscle tissues? And wouldn't less energy produced by the muscle tissues cause them work less efficiently?
 
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Adrenaline!

Epinephrine acts by binding to a variety of adrenergic receptors. Epinephrine is a nonselective agonist of all adrenergic receptors, including the major subtypes α1, α2, β1, β2, and β3.[15] Epinephrine's binding to these receptors triggers a number of metabolic changes. Binding to α-adrenergic receptors inhibits insulin secretion by the pancreas, stimulates glycogenolysis in the liver and muscle, and stimulates glycolysis in muscle.[20]

http://en.wikipedia.org/wiki/Epinephrine#Mechanism_of_action

Reference [20] (a textbook):

http://books.google.ca/books?id=zFl...s+of+Medical+Physiology&source=gbs_navlinks_s
 
Overall ongoing research also confirms that muscles can increase their glucose uptake
via other receptors or channels independent of INSULIN also.
Adrenaline pumps them up !

reference Ganong medical physiologe 23 edition.
 
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Manish7 said:
reference Ganong medical physiologe 23 edition.
Please post a link to the specific passage you are referencing in this book. Thank you. The book is copyrighted, so you may only quote the specific passage.
 
https://www.discovermagazine.com/the-deadliest-spider-in-the-world-ends-lives-in-hours-but-its-venom-may-inspire-medical-miracles-48107 https://en.wikipedia.org/wiki/Versutoxin#Mechanism_behind_Neurotoxic_Properties https://www.sciencedirect.com/science/article/abs/pii/S0028390817301557 (subscription or purchase requred) he structure of versutoxin (δ-atracotoxin-Hv1) provides insights into the binding of site 3 neurotoxins to the voltage-gated sodium channel...
Popular article referring to the BA.2 variant: Popular article: (many words, little data) https://www.cnn.com/2022/02/17/health/ba-2-covid-severity/index.html Preprint article referring to the BA.2 variant: Preprint article: (At 52 pages, too many words!) https://www.biorxiv.org/content/10.1101/2022.02.14.480335v1.full.pdf [edited 1hr. after posting: Added preprint Abstract] Cheers, Tom
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