How Do Molecules Pass Through Fenestrated Capillaries?

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Fenestrated capillaries feature small openings, or pores, in the endothelial cells that allow for increased permeability compared to continuous capillaries. These pores are not covered by a lipid membrane, as they are integral parts of the cell structure, allowing for selective passage of molecules. The presence of a basal lamina surrounding the capillaries plays a crucial role in regulating the movement of substances. Molecules can pass through the pores in the endothelial cells and then interact with the basal lamina, which may filter or facilitate further transport depending on the size and nature of the molecules. Understanding this mechanism is essential for comprehending how substances are exchanged in tissues with fenestrated capillaries, such as the kidneys and intestines.
sameeralord
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Hello everyone,

In fenestrated capillary there are holes inside the endothelial cell, I don't understand how cells can have holes? Does this mean that individual holes in endothelial cells are covered by a lipid membrane? Can anyone tell how can there be holes in an individual cells when lipid membrane usually covers the whole cell. Thanks :smile:

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Now I realized each capillary is covered by a basal lamina, now how do the molecules pass through this after they pass through the pores?
 
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