Suppose you start with a system of N particles identified by position vectors r_1, r_2, \ldots, r_N and masses \mu_1, \mu_2, \ldots, \mu_N. Then (quantum mechanically) the kinetic energy operator for this system is given by (assuming \hbar = 1)
T = \sum_{i = 1}^N -\frac{\Delta_i}{2\mu_i}...