Calculating amplifier efficiency using the formula P output/P input x 100 does not yield the same results as using RMS input and output values. Efficiency is defined as the power delivered to a resistive load divided by the DC power supplied to the amplifier, expressed as a percentage. The power into the resistive load is derived from the AC voltage across that load. In contrast, the power supplied to the amplifier is calculated by multiplying the DC supply voltage by the DC current flowing through the transistors. Understanding these distinctions is crucial for accurate efficiency calculations in amplifiers.