No, all transfers and absolutely anything related to computers is done at the power of 2 number system because it represents the binary system. I think the confusion stems from the fact that we conveniently use "kilobyte" and "megabyte" and "gigabyte". We think of kilo and mega and immediately "1000" comes to our mind when in actuality, it should be 1024 (or 1024 * 1024 for megabyte). Thats where a lot of confusion comes in with hard drives. They'll create say, a 80 billion byte hard drive and say "Look at this 80 GB hard drive". It'll have exactly 80,000,000,000 bytes but when the computer reads it, it reads it in the base 2 system and when it displays a gigabyte number, it'll display 80,000,000,000 / (1024 * 1024) and it'll display around 74GB.
Oddly enough, I wonder why they do create hard drives of 80,000,000,000 bytes or other flat numbers like that. I thought everything was done in packets or sector or something like that and they had values of 32K and 64K and 128K etc etc. Sounds like towards the end, a few or maybe a lot of bytes are lost because they don't have a full packet or sector or whatever.